Arginine Helps Wound Healing

Therapeutic advances has cause the use of specific nutritional supplementation with l-arginine for protein synthesis, production of nitric oxide (NO) and cell proliferation via the ornithine and polyamine metabolism. NO plays a role in wound healing. Effect of NO in wound healing due to effects on angiogenesis, inflammation, cell proliferation, matrix deposition and remodeling. L-Arginine is classified as non-essential amino acid that becomes conditionally essential amino acid on the state of stress. l arginine has been shown to help wound healing and deposit collagen in the wound incision made in animals and humans.
Research shows that the role of dietary intervention in the form of arginine supplementation also shown to provide benefits in wound healing. Levels of nitrate in wound fluid were significantly higher than in plasma throughout the period and the molar ratio of nitrate to nitrite increases. This is associated with increased ornithine and urea gradually increased and decreased arginine and phenylalanine in the wound. Glycine decreased gradually to the molar ratio of branched chain amino acids is gradually also found in plasma or in wound fluid. Need to do further study on the application on wound healing in humans. Although the hypothesis that arginine can helps wound healing is often discussed, but the therapeutic effect of arginine supplementation on chronic wound healing in humans still needs further study. Clinical trials are designed with both needed to determine whether arginine supplementation is effective in helping the healing of acute and chronic wounds in humans and how many doses of arginine is recommended to meet the needs during the phases of wound healing.